A tale of two compounds.

نویسنده

  • Bruce C Gibb
چکیده

In 1947, Richard A. Robson described the synthesis of 8-(γ-diethylaminopropylamino)isoquinoline1. Why this particular molecule was targeted was not made clear in the paper. Moreover, as this is the only time this compound had been reported so far, it is difficult to determine precisely what he and his employer — G. D. Searle and Company — had in mind beyond their focus on pharmaceuticals, agriculture and animal health. This compound is not, however, central to this essay. Rather, one of the intermediates in the synthesis is. For this was apparently the first time 8-hydroxyisoquinoline (1) was synthesized and isolated.

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عنوان ژورنال:
  • Nature chemistry

دوره 3 10  شماره 

صفحات  -

تاریخ انتشار 2011